Nevus anemicus typically presents as an isolated lesion with no other systemic manifestations. Nevus anemicus has a slight female preponderance. Intralesional injection of bradykinin, acetylcholine, serotonin, nicotine, 5-hydroxytryptamine, and histamine fails to induce the anticipated vasodilatation or erythema in the affected area.

Nevus anemicus is not present in Legius syndrome, which mimics neurofibromatosis type 1 by the presence of cafe au lait macules and intertriginous freckling. Interestingly, nevus anemicus has been reported to be resistant to dermatophyte infections such as Trichophyton rubrum, which was postulated to be due to the reduced blood flow and lower temperature of the lesional skin. [CDATA[// >

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